GSK180736A

    • Catalog No.:MC1382
      • CasNo:
      • 817194-38-0
      • MolecularFormula:
      • C19H16FN5O2
      • Purity:
      • >98%
      • Target:
      • ROCK
      • IC50:
      • IC50: 0.77 μM (GRK2), 100 nM (ROCK1)[1]
      • In Vitro:
      • GSK180736A is a compound structurally similar to paroxetine that is developed as a ROCK inhibitor, is shown to be an even more potent and selective inhibitor of GRK2 with an IC50 of 0.77 μM and more than 100-fold selectivity over other GRKs. ROCK1 is a potential therapeutic target in the treatment of cardiovascular diseases such as hypertension. GSK180736A is a weak inhibitor of PKA with an IC50 of 30 μM, but highly potent against ROCK1 (IC50=100 nM)[1].
      • Fields:
      • GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
      • Specificity:
      • Target: ROCK. Fields: GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
      • Dilution:
      • IC50: 0.77 μM (GRK2), 100 nM (ROCK1)[1]
      • Concentration:
      • >98%
      • Storage Stability:
      • 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
      • Other Name:
      • GSK 180736A; GSK-180736A
      • MolecularWeight(Da):
      • 365.36
      • Products Images