Celastrol

    • Catalog No.:MC0004
      • CasNo:
      • 34157-83-0,956288-52-1(sodiumsalt)
      • MolecularFormula:
      • C29H38O4
      • Purity:
      • >99%
      • Target:
      • Proteasome
      • IC50:
      • IC50: 2.5 μM (20S proteasome)[1]
      • In Vitro:
      • Celastrol significantly inhibits the proteasomal chymotrypsin activity in PC-3 cells in a concentration-dependent manner; at 2.5 μM it reaches ∼55% inhibition, comparable to its potency to a purified 20S proteasome (IC50=2.5 μM). Furthermore, increased levels of IκB-α, Bax, and p27 are observed, three well known target proteins of the proteasome in PC-3 cells treated with Celastrol[1].
      • In Vivo:
      • Treatment of PC-3 tumor-bearing nude mice with Celastrol (1-3 mg/kg/d, i.p., 1-31 days) results in significant inhibition (65-93%) of the tumor growth[1]. Following treatment with 3 and 6 mg/kg Celastrol, the levels of malondialdehyde (MDA) are significantly decreased by 35.2 and 36.7% (P<0.05), respectively. Treatment with 3 and 6 mg/kg Celastrol markedly restores the GSH level (P<0.05) to almost normal levels[2].
      • Fields:
      • Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM.
      • Specificity:
      • Target: Proteasome. Fields: Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM.
      • Source:
      • Rabbit
      • Dilution:
      • IC50: 2.5 μM (20S proteasome)[1]
      • Concentration:
      • >99%
      • Storage Stability:
      • 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
      • MolecularWeight(Da):
      • 450.61
      • References:
      • [1]. Yang H, et al. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 200
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