• Gene Name：
• MAP3K7

• Human Gene Id：
• 6885

• Human Swiss Prot No：
• O43318

• Mouse Swiss Prot No：
• Q62073

• Rat Swiss Prot No：
• P0C8E4

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)

• Detection Method：
• Colorimetric

• Background：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF-kappa-B activation and the p38 MAPK pathway.,PTM:Association with MAP3K7IP1 promotes autophosphorylation and subsequent activation. Dephosphorylation at Thr-187 by PP2A and PPP6C leads to inactivation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with MAP3K7IP1 and MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its' repressed activity.,

• Function：
• MAPKKK cascade, angiogenesis, blood vessel development, regulation of cytokine production, positive regulation of cytokine production, embryonic epithelial tube formation, neural tube formation, vasculature development,morphogenesis of an epithelium, activation of immune response, immune response-activating cell surface receptor signaling pathway, positive regulation of immune system process, regulation of leukocyte activation, positive regulation of leukocyte activation, regulation of immune effector process, positive regulation of immune effector process, regulation of production of molecular mediator of immune response, positive regulation of production of molecular mediator of immune response, regulation of leukocyte mediated immunity, positive regulation of leukocyte mediated immunity, regulation of lymphocyte mediated immunity, positive regulation of lymphocyte mediated immunity,re

• Subcellular Location：
• Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane.

• Expression：
• Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form.

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