• Gene Name：
• PPP1R12A

• Human Gene Id：
• 4659

• Human Swiss Prot No：
• O14974

• Mouse Swiss Prot No：
• Q9DBR7

• Rat Swiss Prot No：
• Q10728

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)

• Detection Method：
• Colorimetric

• Background：
• function:Regulates myosin phosphatase activity.,PTM:Phosphorylated by CIT (Rho-associated kinase) (By similarity). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-696. Phosphorylated on upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Contains 6 ANK repeats.,subcellular location:Along actomyosin filaments and stress fibers.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12A mediates binding to myosin. Interacts with ARHA and CIT (By similarity). Binds PPP1R12B, ROCK1 and IL16.,

• Subcellular Location：
• Cytoplasm . Cytoplasm, cytoskeleton, stress fiber . Also along actomyosin filaments. .

• Expression：
• Expressed in striated muscles, specifically in type 2a fibers (at protein level).

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