• 靶点：
• INDOL1

• 简介：
• >>Tryptophan metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors;>>African trypanosomiasis

• 基因名称：
• IDO2

• 蛋白名称：
• Indoleamine 2,3-dioxygenase 2

• Human Gene Id：
• 169355

• Human Swiss Prot No：
• Q6ZQW0

• Mouse Swiss Prot No：
• Q8R0V5

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human IDO2. AA range:101-150

• 特异性：
• INDOL1 Polyclonal Antibody detects endogenous levels of INDOL1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• IDO2;INDOL1;Indoleamine 2,3-dioxygenase 2;IDO-2;Indoleamine 2,3-dioxygenase-like protein 1;Indoleamine-pyrrole 2,3-dioxygenase-like protein 1

• 实测条带：
• 45kD

• 背景：
• Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011],

• 功能：
• tryptophan metabolic process, tryptophan catabolic process, cellular amino acid derivative metabolic process, biogenic amine metabolic process, indolalkylamine metabolic process, cellular amino acid catabolic process, aromatic amino acid family metabolic process, aromatic amino acid family catabolic process, amine catabolic process, organic acid catabolic process, aromatic compound catabolic process, tryptophan catabolic process to kynurenine, cellular amino acid derivative catabolic process, biogenic amine catabolic process, indole and derivative metabolic process, indole derivative metabolic process, indole derivative catabolic process, indolalkylamine catabolic process, carboxylic acid catabolic process, heterocycle catabolic process, oxidation reduction,

• 细胞定位：
• cytoplasm,cytosol,integral component of membrane,

• 组织表达：
• Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon (PubMed:17671174). Also expressed at low level in testis and thyroid. Not expressed in the majority of human tumor samples (>99%) (PubMed:25691885).

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