• 靶点：
• TudorSN

• 简介：
• >>Viral carcinogenesis

• 基因名称：
• SND1

• 蛋白名称：
• Staphylococcal nuclease domain-containing protein 1

• Human Gene Id：
• 27044

• Human Swiss Prot No：
• Q7KZF4

• Mouse Gene Id：
• 56463

• Mouse Swiss Prot No：
• Q78PY7

• Rat Gene Id：
• 64635

• Rat Swiss Prot No：
• Q66X93

• 免疫原：
• Synthesized peptide derived from the Internal region of human TudorSN.

• 特异性：
• TudorSN Polyclonal Antibody detects endogenous levels of TudorSN protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SND1;TDRD11;Staphylococcal nuclease domain-containing protein 1;100 kDa coactivator;EBNA2 coactivator p100;Tudor domain-containing protein 11;p100 co-activator

• 实测条带：
• 101kD

• 背景：
• This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016],

• 功能：
• function:Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).,PTM:Phosphorylated by PIM1 in vitro.,sequence caution:The frameshift leads to wrong initation.,similarity:Contains 1 Tudor domain.,similarity:Contains 4 TNase-like domains.,subcellular location:In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Binds to acidic transactivation domain of EBNA2. Interacts with EAV NSP1. Interacts with GTF2E1 and GTF2E2. Forms a ternary complex with STAT6 and POLR2A. Interacts with STAT5.,tissue specificity:Ubiquitously expressed.,

• 细胞定位：
• Cytoplasm . Nucleus . Melanosome . In IL-4 stimulated cells colocalizes with STAT6 in the nucleus (PubMed:12234934). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .

• 组织表达：
• Ubiquitously expressed.

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