Tie-2 Polyclonal Antibody

  • 货号:YT4651
  • 应用:WB,ELISA
  • 种属:Human,Mouse
    • 基因名称:
    • TEK
    • 蛋白名称:
    • Angiopoietin-1 receptor
    • Human Gene Id:
    • 7010
    • Human Swiss Prot No:
    • Q02763
    • Mouse Swiss Prot No:
    • Q02858
    • 免疫原:
    • Synthesized peptide derived from Tie-2 . at AA range: 930-1010
    • 特异性:
    • Tie-2 Polyclonal Antibody detects endogenous levels of Tie-2 protein.
    • 组成:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源:
    • Rabbit
    • 稀释:
    • Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
    • 纯化工艺:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度:
    • 1 mg/ml
    • 储存:
    • -20°C/1 year
    • 其他名称:
    • TEK; TIE2; VMCM; VMCM1; Angiopoietin-1 receptor; Endothelial tyrosine kinase; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor
    • 分子量:
    • 125811
    • 实测条带:
    • 125
    • 背景:
    • TEK receptor tyrosine kinase(TEK) Homo sapiens This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014],
    • 功能:
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in TEK are a cause of dominantly inherited venous malformations (VMCM) [MIM:600195]; an error of vascular morphogenesis characterized by dilated, serpiginous channels.,function:This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Cont
    • 细胞定位:
    • stress fiber,extracellular region,cytoplasm,cytoskeleton,actin filament,plasma membrane,integral component of plasma membrane,microvillus,cell-cell junction,focal adhesion,basal plasma membrane,cell surface,ba
    • 组织表达:
    • Brain,Liver,Pancreas,Placenta,