• 靶点：
• NHE-8

• 基因名称：
• SLC9A8

• 蛋白名称：
• Sodium/hydrogen exchanger 8

• Human Gene Id：
• 23315

• Human Swiss Prot No：
• Q9Y2E8

• Mouse Gene Id：
• 77031

• Mouse Swiss Prot No：
• Q8R4D1

• Rat Gene Id：
• 311651

• Rat Swiss Prot No：
• Q4L208

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human SLC9A8. AA range:451-500

• 特异性：
• NHE-8 Polyclonal Antibody detects endogenous levels of NHE-8 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000.IHC:1:50-300 ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SLC9A8;KIAA0939;NHE8;Sodium/hydrogen exchanger 8;Na(+)/H(+) exchanger 8;NHE-8;Solute carrier family 9 member 8

• 实测条带：
• 65kD

• 背景：
• Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009],

• 功能：
• function:Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.,similarity:Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.,tissue specificity:Ubiquitous. Strongly expressed in skeletal muscle and kidney.,

• 细胞定位：
• Golgi apparatus membrane ; Multi-pass membrane protein .

• 组织表达：
• Ubiquitous. Strongly expressed in skeletal muscle and kidney.

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