• 靶点：
• MYLIP

• 简介：
• >>Cholesterol metabolism

• 基因名称：
• MYLIP

• 蛋白名称：
• E3 ubiquitin-protein ligase MYLIP

• Human Gene Id：
• 29116

• Human Swiss Prot No：
• Q8WY64

• Mouse Gene Id：
• 218203

• Mouse Swiss Prot No：
• Q8BM54

• Rat Gene Id：
• 306825

• Rat Swiss Prot No：
• D3ZDI6

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human MYLIP. AA range:161-210

• 特异性：
• MYLIP Polyclonal Antibody detects endogenous levels of MYLIP protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MYLIP;BZF1;IDOL;BM-023;PP5242;E3 ubiquitin-protein ligase MYLIP;Inducible degrader of the LDL-receptor;Idol;Myosin regulatory light chain interacting protein;MIR

• 实测条带：
• 50kD

• 背景：
• The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008],

• 功能：
• developmental stage:Expressed in fetal tissues and higher levels were detected in placenta and fetal lung.,domain:The RING domain mediates ubiquitination and the neurite outgrowth inhibitory activity.,function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Stable or transient overexpression of MIR induces proteasomal degradation of MRLC inhibiting neurite outgrowth in presence of NGF. MIR counteracts the stabilization of MRLC by MIR-interacting saposin-like protein (MSAP/TMEM4) and reduces MSAP-stimulated neurite outgrowth.,pathway:Protein modification; protein ubiquitination.,PTM:Autoubiquitinated.,similarity:Contains 1 FERM domain.,similarity:Contains 1 RING-type zinc finger.,subunit:Interacts with myosin regulatory light chain (MRLC) and TMEM4.,tissue specificity:Ubiquitously expressed.,

• 细胞定位：
• Cytoplasm . Cell membrane ; Peripheral membrane protein .

• 组织表达：
• Ubiquitously expressed.

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