MRP2 Polyclonal Antibody

    • 货号:YT2840
    • 应用:WB;ELISA
    • 种属:Human;Rat;Mouse;
      • 靶点:
      • MRP2
      • 简介:
      • >>Antifolate resistance;>>Platinum drug resistance;>>ABC transporters;>>Bile secretion
      • 基因名称:
      • ABCC2
      • 蛋白名称:
      • Canalicular multispecific organic anion transporter 1
      • Human Gene Id:
      • 1244
      • Human Swiss Prot No:
      • Q92887
      • Mouse Swiss Prot No:
      • Q8VI47
      • 免疫原:
      • The antiserum was produced against synthesized peptide derived from human ABCC2. AA range:991-1040
      • 特异性:
      • MRP2 Polyclonal Antibody detects endogenous levels of MRP2 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • ABCC2;CMOAT;CMOAT1;CMRP;MRP2;Canalicular multispecific organic anion transporter 1;ATP-binding cassette sub-family C member 2;Canalicular multidrug resistance protein;Multidrug resistance-associated protein 2
      • 分子量:
      • 175kD
      • 实测条带:
      • 190-250kD
      • 背景:
      • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008],
      • 功能:
      • disease:Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.,function:Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.,
      • 细胞定位:
      • Apical cell membrane ; Multi-pass membrane protein .
      • 组织表达:
      • Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.

      The potentially protective role of ATP-binding cassette transporters in preeclampsia via Nrf2. Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health WB Human placental
      货号:YT2840

      • 产品图片
      • Western Blot analysis of 3T3 cells using MRP2 Polyclonal Antibody diluted at 1:1000
      • Western blot analysis of ABCC2 Antibody. The lane on the right is blocked with the ABCC2 peptide.
      • Western blot analysis of the lysates from HeLa cells using ABCC2 antibody.