- 靶点:
- MRP2
- 简介:
- >>Antifolate resistance;>>Platinum drug resistance;>>ABC transporters;>>Bile secretion
- 基因名称:
- ABCC2
- 蛋白名称:
- Canalicular multispecific organic anion transporter 1
- Human Gene Id:
- 1244
- Human Swiss Prot No:
- Q92887
- Mouse Swiss Prot No:
- Q8VI47
- 免疫原:
- The antiserum was produced against synthesized peptide derived from human ABCC2. AA range:991-1040
- 特异性:
- MRP2 Polyclonal Antibody detects endogenous levels of MRP2 protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度:
- 1 mg/ml
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- ABCC2;CMOAT;CMOAT1;CMRP;MRP2;Canalicular multispecific organic anion transporter 1;ATP-binding cassette sub-family C member 2;Canalicular multidrug resistance protein;Multidrug resistance-associated protein 2
- 分子量:
- 175kD
- 实测条带:
- 190-250kD
- 背景:
- The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008],
- 功能:
- disease:Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.,function:Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.,
- 细胞定位:
- Apical cell membrane ; Multi-pass membrane protein .
- 组织表达:
- Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.
The potentially protective role of ATP-binding cassette transporters in preeclampsia via Nrf2. Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health WB Human placental
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- Antibody-FAQs
- 产品图片
- Western Blot analysis of 3T3 cells using MRP2 Polyclonal Antibody diluted at 1:1000
- Western blot analysis of ABCC2 Antibody. The lane on the right is blocked with the ABCC2 peptide.
- Western blot analysis of the lysates from HeLa cells using ABCC2 antibody.