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D4DR Polyclonal Antibody

货号：YT1278
应用：WB;IF;ELISA
种属：Human;Mouse;Rat

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靶点：
D4DR

简介：
>>Neuroactive ligand-receptor interaction;>>Dopaminergic synapse

基因名称：
DRD4

蛋白名称：
D(4) dopamine receptor

Human Gene Id：
1815

Human Swiss Prot No：
P21917

Mouse Gene Id：
13491

Mouse Swiss Prot No：
P51436

Rat Gene Id：
25432

Rat Swiss Prot No：
P30729

免疫原：
The antiserum was produced against synthesized peptide derived from human DRD4. AA range:355-404

特异性：
D4DR Polyclonal Antibody detects endogenous levels of D4DR protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
DRD4;D(4) dopamine receptor;D(2C) dopamine receptor;Dopamine D4 receptor

实测条带：
48kD

背景：
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008],

功能：
function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.,polymorphism:The number of repeats of 16 amino acids in the third cytoplasmic loop is highly polymorphic and varies among different alleles. Alleles corresponding in size to a 2 (D4.2), 3 (D4.3), 4 (D4.4), 5 (D4.5), 6 (D4.6), 7 (D4.7) and 9 (D4.9) repeats have been described. The sequence shown is that of allele D4.7. The polymorphic repeat sequence has little influence on DRD4-binding profiles and might not be essential for G protein interaction.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with CLIC6 (By similarity) and GPRASP1.,

细胞定位：
Cell membrane ; Multi-pass membrane protein .

组织表达：
Highly expressed in retina. Detected at much lower levels in brain, in amygdala, thalamus, hypothalamus, cerebellum and pituitary.

Does genetic mouse model of constitutive Hint1 deficiency exhibit schizophrenia-like behaviors?. SCHIZOPHRENIA RESEARCH 2020 May 18 WB Mouse 1:500 Medial prefrontal cortex (mPFC), nucleus accumbens (NAc), and hippocampus (Hip)
货号：YT1278