• 靶点：
• D1DR

• 简介：
• >>Calcium signaling pathway;>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Gap junction;>>Dopaminergic synapse;>>Parkinson disease;>>Cocaine addiction;>>Amphetamine addiction;>>Morphine addiction;>>Alcoholism

• 基因名称：
• DRD1

• 蛋白名称：
• D(1A) dopamine receptor

• Human Gene Id：
• 1812

• Human Swiss Prot No：
• P21728

• Mouse Gene Id：
• 13488

• Mouse Swiss Prot No：
• Q61616

• Rat Gene Id：
• 24316

• Rat Swiss Prot No：
• P18901

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human DRD1. AA range:135-184

• 特异性：
• D1DR Polyclonal Antibody detects endogenous levels of D1DR protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• DRD1;D(1A) dopamine receptor;Dopamine D1 receptor

• 实测条带：
• 50kD

• 背景：
• This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008],

• 功能：
• function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.,subunit:Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP.,tissue specificity:Detected in caudate, nucleus accumbens and in the olfactory tubercle.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, dendritic spine . Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. .

• 组织表达：
• Detected in caudate, nucleus accumbens and in the olfactory tubercle.

Developmental Exposure to Atrazine Impairs Spatial Memory and Downregulates the Hippocampal D1 Dopamine Receptor and cAMP-Dependent Signaling Pathway in Rats. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Int J Mol Sci. 2018 Aug;19(8):2241 WB,IHC Rat 1:100,1:1000 hippocampal tissue
货号：YT1277

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