• 靶点：
• Cdc5L

• 简介：
• >>Spliceosome

• 基因名称：
• CDC5L

• 蛋白名称：
• Cell division cycle 5-like protein

• Human Gene Id：
• 988

• Human Swiss Prot No：
• Q99459

• Mouse Gene Id：
• 71702

• Mouse Swiss Prot No：
• Q6A068

• Rat Gene Id：
• 85434

• Rat Swiss Prot No：
• O08837

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CDC5L. AA range:721-770

• 特异性：
• Cdc5L Polyclonal Antibody detects endogenous levels of Cdc5L protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CDC5L;KIAA0432;PCDC5RP;Cell division cycle 5-like protein;Cdc5-like protein;Pombe cdc5-related protein

• 分子量：
• 92kD

• 背景：
• The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008],

• 功能：
• disease:A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation t(6;19)(p21;q13.1) with USF2.,function:DNA-binding protein involved in cell cycle control. May act as a transcription activator. Also seems to be involved in the second catalytic step of pre-mRNA splicing.,PTM:Phosphorylated; which enhances interaction with PPP1R8.,similarity:Belongs to the CEF1 family.,similarity:Contains 2 HTH myb-type DNA-binding domains.,subcellular location:May shuttle between cytoplasm and nucleus.,subunit:Homodimer. Interacts with DAPK3 (By similarity). Binds to DNA. Binds to adeno-pre-mRNA in an ATP-stimulated manner. Belongs to the spliceosome complex. Part of a spliceosomal 'core' complex consisting of CDC5L, PLRG1, SPF27, CCAP1, CCAP3 and CCAP6. Interacts with PLRG1, Lodestar/TTF2, and NIPP1/PPP1R8. Identified in the spliceosome C complex, at least composed

• 细胞定位：
• Nucleus . Nucleus speckle . Cytoplasm . May shuttle between cytoplasm and nucleus. .

• 组织表达：
• Ubiquitously expressed in both fetal and adult tissues.

• June 19-2018
• WESTERN IMMUNOBLOTTING PROTOCOL

• June 19-2018
• IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL

• June 19-2018
• IMMUNOFLUORESCENCE PROTOCOL

• September 08-2020
• FLOW-CYTOMEYRT-PROTOCOL

• May 20-2022
• Cell-Based ELISA│解您多样本WB检测之困扰

• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN

• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN

• July 13-2018
• CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN

• July 13-2018
• Antibody-FAQs