• 靶点：
• CDC20

• 简介：
• >>Cell cycle;>>Oocyte meiosis;>>Ubiquitin mediated proteolysis;>>Human T-cell leukemia virus 1 infection;>>Viral carcinogenesis

• 基因名称：
• CDC20

• 蛋白名称：
• Cell division cycle protein 20 homolog

• Human Gene Id：
• 991

• Human Swiss Prot No：
• Q12834

• Mouse Gene Id：
• 107995

• Mouse Swiss Prot No：
• Q9JJ66

• Rat Gene Id：
• 64515

• Rat Swiss Prot No：
• Q62623

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human p55CDC. AA range:81-130

• 特异性：
• Cdc20 Polyclonal Antibody detects endogenous levels of Cdc20 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CDC20;Cell division cycle protein 20 homolog;p55CDC

• 实测条带：
• 50kD

• 背景：
• CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008],

• 功能：
• developmental stage:Synthesis is initiated at G1/S, protein level peaks in M phase and protein is abruptly degraded at M/G1 transition.,function:Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1. In metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated during mitosis, probably by maturation promoting factor (MPF).,PTM:Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint.,similarity:Belongs to the WD repeat CDC20/Fizzy family.,similarity:Contains 7 WD repeats.,subunit:Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with SPATC1 (By similarity). Interacts with MAD2L

• 细胞定位：
• Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole .

• 组织表达：
• Colon,Colon adenocarcinoma,Liver,Lymph,Muscle,Ovary,Skin,Spleen,Testis,

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