• 靶点：
• YAP

• 简介：
• >>Hippo signaling pathway;>>Hippo signaling pathway - multiple species

• 基因名称：
• YAP1

• 蛋白名称：
• Yorkie homolog

• Human Gene Id：
• 10413

• Human Swiss Prot No：
• P46937

• Mouse Gene Id：
• 22601

• Mouse Swiss Prot No：
• P46938

• Rat Gene Id：
• 363014

• Rat Swiss Prot No：
• Q2EJA0

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:100-1:500;WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• YAP1;YAP65;Yorkie homolog;65 kDa Yes-associated protein;YAP65

• 分子量：
• 55kD

• 实测条带：
• 55-75kD

• 背景：
• This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013],

• 功能：
• PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 WW domain.,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif.,

• 细胞定位：
• Cytoplasm, Nucleus

• 组织表达：
• Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level).

S100A1 is a Potential Biomarker for Papillary Thyroid Carcinoma Diagnosis and Prognosis. Journal of Cancer J Cancer. 2021; 12(19): 5760–5771 WB Human 1:500 Papillary thyroid carcinoma（PTC）tissues，paired normal thyroid tissues
货号：YM8331

Targeting the mechanism of IRF3 in sepsis-associated acute kidney injury via the Hippo pathway. Xingui Dai WB Human HK-2 cell
货号：YM8331

Alpha-fetoprotein upregulates hepatocellular carcinoma cell-intrinsic PD-1 expression through the LATS2/YAP/TEAD1 pathway BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS Guangxian Leng WB,IF Human 1:1000,1:500 Huh-7 cell,HLE cell
货号：YM8331

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