• 靶点：
• OCLN

• 简介：
• >>Cell adhesion molecules;>>Tight junction;>>Leukocyte transendothelial migration;>>Pathogenic Escherichia coli infection;>>Hepatitis C

• 基因名称：
• OCLN

• 蛋白名称：
• Occludin;OCN

• Human Gene Id：
• 100506658

• Human Swiss Prot No：
• Q16625

• Mouse Swiss Prot No：
• Q61146

• Rat Swiss Prot No：
• Q6P6T5

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 59kD

• 实测条带：
• 65kD

• 背景：
• This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011],

• 功能：
• protein complex assembly, cellular amino acid derivative metabolic process, sulfur metabolic process, nucleoside metabolic process, ribonucleoside metabolic process, purine nucleoside metabolic process, macromolecular complex subunit organization, purine ribonucleoside metabolic process, S-adenosylhomocysteine metabolic process, S-adenosylmethionine metabolic process, macromolecular complex assembly, protein complex biogenesis,

• 细胞定位：
• Membrane

• 组织表达：
• Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.

Tyrosol inhibits NF-κB pathway in the treatment of enterotoxigenic Escherichia coli-induced diarrhea in mice MICROBIAL PATHOGENESIS Fazheng Yu, Jian Guo, Hong lin Ren, Shiying Lu, Zhaoqi He, Jiang Chang, Xueyu Hu, Ruoran Shi, Yuanyuan Jin, Yansong Li, Zengshan Liu, Xiaoxu Wang, Pan Hu WB Mouse colonic tissue
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PTH1-34 promotes osteoblast formation through Beclin1-dependent autophagic activation. JOURNAL OF BONE AND MINERAL METABOLISM J Bone Miner Metab. 2021 Jul;39(4):572-582 WB，IHC Mouse 1 : 200 Tibiae MC3T3-E1 cell
货号：YM8316

Bacillus subtilis RZ001 improves intestinal integrity and alleviates colitis by inhibiting the Notch signalling pathway and activating ATOH-1. Pathogens and Disease Pathog Dis. 2020 Mar;78(2): WB Human HT-29 cell
货号：YM8316

Human placental mesenchymal stromal cells modulate IFN-γ and IL-10 secretion by CD4+T cells via CD73, and alleviate intestinal damage in mice with graft-versus-host disease. INTERNATIONAL IMMUNOPHARMACOLOGY Xiying Luan WB Human，Mouse intestine,colon NCM460 cell,Caco-2 cell
货号：YM8316

ZEA mediates autophagy through the ROS-AMPK-m-TOR pathway to enhance the susceptibility of mastitis induced by Staphylococcus aureus in mice. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Xiaoyu Hu WB Mouse mammary gland tissues mouse mammary epithelial cells (MMEC)
货号：YM8316

hPMSCs Regulate the Level of TNF-α and IL-10 in Th1 Cells and Improve Hepatic Injury in a GVHD Mouse Model via CD73/ADO/Fyn/Nrf2 Axis. INFLAMMATION Luan Xiying IF Human human placental-derived MSCs (hPMSCs)
货号：YM8316

The Synbiotic Combination of probiotics and inulin Improves NAFLD though Modulating Gut Microbiota JOURNAL OF NUTRITIONAL BIOCHEMISTRY Can Zhang IF Mouse colon tissue
货号：YM8316

Clostridium butyricum upregulates GPR109A/AMPK/PGC-1α and ameliorates acute pancreatitis-associated intestinal barrier injury in mice ARCHIVES OF MICROBIOLOGY Deng Guiqing WB,IHC Mouse 1:400 pancreas tissue, small intestine tissue, colon tissue
货号：YM8316

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