• 靶点：
• FTO

• 基因名称：
• FTO

• 蛋白名称：
• Alpha-ketoglutarate-dependent dioxygenase FTO

• Human Gene Id：
• 79068

• Human Swiss Prot No：
• Q9C0B1

• Mouse Gene Id：
• 26383

• Mouse Swiss Prot No：
• Q8BGW1

• Rat Gene Id：
• 291905

• Rat Swiss Prot No：
• Q2A121

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:4000-1:10000,WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200,

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• FTO;KIAA1752;Alpha-ketoglutarate-dependent dioxygenase FTO;Fat mass and obesity-associated protein

• 分子量：
• 58kD

• 实测条带：
• 58kD

• 背景：
• This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011],

• 功能：
• function:The precise function of this protein remains to be determined.,polymorphism:At least one intronic variation within the gene predisposes to childhood and adult obesity.,similarity:Belongs to the fto family.,tissue specificity:Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.,

• 细胞定位：
• Cytoplasm, Nucleus

• 组织表达：
• Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary (PubMed:17434869, PubMed:17496892). Highly expressed in highly expressed in acute myeloid leukemias (AML) with t(11;11)(q23;23) with KMT2A/MLL1 rearrangements, t(15;17)(q21;q21)/PML-RARA, FLT3-ITD, and/or NPM1 mutations (PubMed:28017614).

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