• 靶点：
• mTOR

• 简介：
• >>EGFR tyrosine kinase inhibitor resistance;>>Endocrine resistance;>>ErbB signaling pathway;>>HIF-1 signaling pathway;>>Phospholipase D signaling pathway;>>Autophagy - other;>>Autophagy - animal;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Cellular senescence;>>Apelin signaling pathway;>>Neutrophil extracellular trap formation;>>JAK-STAT signaling pathway;>>Th17 cell differentiation;>>Thermogenesis;>>Insulin signaling pathway;>>Thyroid hormone signaling pathway;>>Adipocytokine signaling pathway;>>Type II diabetes mellitus;>>Insulin resistance;>>Growth hormone synthesis, secretion and action;>>Alzheimer disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Pathways of neurodegeneration - multiple diseases;>>Shigellosis;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Kaposi sarcoma-associated herpesvirus infection;>>He

• 基因名称：
• MTOR

• 蛋白名称：
• Serine/threonine-protein kinase mTOR

• Human Gene Id：
• 2475

• Human Swiss Prot No：
• P42345

• Mouse Gene Id：
• 56717

• Mouse Swiss Prot No：
• Q9JLN9

• Rat Gene Id：
• 56718

• Rat Swiss Prot No：
• P42346

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MTOR;FRAP;FRAP1;FRAP2;RAFT1;RAPT1;Serine/threonine-protein kinase mTOR;FK506-binding protein 12-rapamycin complex-associated protein 1;FKBP12-rapamycin complex-associated protein;Mammalian target of rapamycin;mTOR;Mechanistic tar

• 分子量：
• 289kD

• 实测条带：
• 260kD

• 检测范围：

• 背景：
• The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008],

• 功能：
• function:Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 FAT domain.,similarity:Contains 1 FATC domain.,similarity:Contains 1 PI3K/PI4K domain.,similarity:Contains 7 HEAT repeats.,subunit:Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian target of rapamycin 2 complex (TORC2) comprised of FRAP1, GBL, PRR5, RICTOR and SIN. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the TORC2 complex.,tissue specificity:Expressed in numerous tissues, with highest levels in testis.,

• 细胞定位：
• Cytoplasm

• 组织表达：
• Expressed in numerous tissues, with highest levels in testis.

CFNC, a neocryptolepine derivative, inhibited the growth of gastric cancer AGS cells by inhibiting PI3K/AKT signaling pathway
货号：YM8208

Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy Molecular Medicine Reports Bing Jiang, Longfei Feng, Tao Yang, Wenjing Guo, Yangyang Li, Tao Wang, Chengguang Liu, Haixiang Su WB Human 97H cell
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Design, synthesis, and cytotoxic activities of isaindigotone derivatives as potential anti-gastric cancer agents. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY2022;37(1):1212-1226. Human AGS cell
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Ammonia inhalation-mediated mir-202-5p leads to cardiac autophagy through PTEN/AKT/mTOR pathway. CHEMOSPHERE Chemosphere. 2019 Nov;235:858 WB Chicken 1:500) heart
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Targeting glycometabolic reprogramming to restore the sensitivity of leukemia drug-resistant K562/ADM cells to adriamycin. LIFE SCIENCES Life Sci. 2018 Dec;215:1 WB Human 1:1000 K562 cell
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Copper induces energy metabolic dysfunction and AMPK-mTOR pathway-mediated autophagy in kidney of broiler chickens. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Ecotox Environ Safe. 2020 Dec;206:111366 WB Chick 1 : 1000 Kidney
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Cadmium induces BNIP3-dependent autophagy in chicken spleen by modulating miR-33-AMPK axis. CHEMOSPHERE 2017 Dec 06 WB Chicken 1:1000 Spleen
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RAPTOR promotes colorectal cancer proliferation by inducing mTORC1 and upregulating ribosome assembly factor URB1. Cancer Medicine Cancer Med-Us. 2020 Feb;9(4):1529-1543 WB Human 1:2000 RKO cell, SW480 cell, HCT116 cell,LoVo cell
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Manganese Chloride Exposure Causes Disorder of Energy Metabolism and Induces Oxidative Stress and Autophagy in Chicken Liver. BIOLOGICAL TRACE ELEMENT RESEARCH Biol Trace Elem Res. 2020 Sep;197(1):254-261 WB Chicken 1:1000 Liver
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Anti-apoptotic and apoptotic pathway analysis of arsenic trioxide‑induced apoptosis in human gastric cancer SGC-7901 cells. ONCOLOGY REPORTS 2014 Jun 20 WB Human 1:800 SGC-7901 cell
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MicroRNA-7-5p regulates human alveolar epithelial sodium channels by targeting the mTORC2/SGK-1 signaling pathway. EXPERIMENTAL LUNG RESEARCH 2016 Jun 22 WB Human 1:1000 A549 cell
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Electro-acupuncture attenuates the mice premature ovarian failure via mediating PI3K/AKT/mTOR pathway. LIFE SCIENCES 2018 Dec 03 WB Mouse 1:1000 ovary tissues
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Short communication: Relationship between lysine/methionine ratios and glucose levels and their effects on casein synthesis via activation of the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells. JOURNAL OF DAIRY SCIENCE 2019 Jul 17 WB Bovine mammary epithelial cell
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The role and regulatory mechanism of autophagy in hippocampal nerve cells of piglet damaged by deoxynivalenol. TOXICOLOGY IN VITRO Toxicol In Vitro. 2020 Aug;66:104837 WB Pig 1:1000 piglet hippocampal nerve cells (PHNCs)
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Autophagy enhanced antitumor effect in K562 and K562/ADM cells using realgar transforming solution. BIOMEDICINE & PHARMACOTHERAPY 2017 Dec 27 WB Human K562 cell
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Methylation-induced silencing of miR-34a enhances chemoresistance by directly upregulating ATG4B-induced autophagy through AMPK/mTOR pathway in prostate cancer. ONCOLOGY REPORTS 2015 Oct 16 WB Human PC-3 cell, DU145 cell
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Water‑soluble nano‑pearl powder promotes MC3T3‑E1 cell differentiation by enhancing autophagy via the MEK/ERK signaling pathway. Molecular Medicine Reports Mol Med Rep. 2018 Jul;18(1):993-1000 WB Mouse 1:1000 MC3T3-E1 cell
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Glycometabolic adaptation mediates the insensitivity of drug-resistant K562/ADM leukaemia cells to adriamycin via the AKT-mTOR/c-Myc signalling pathway. Molecular Medicine Reports Mol Med Rep. 2017 Apr;15(4):1869-1876 WB Human 1:1000 K562/ADM cell
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Peroxisome proliferator‑activated receptor‑γ agonist inhibits the mammalian target of rapamycin signaling pathway and has a protective effect in a rat model of status epilepticus. Molecular Medicine Reports Mol Med Rep. 2015 Aug;12(2):1877-1883 WB Rat 1:500 hippocampal tissues
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Outer membrane protein a in Acinetobacter baumannii induces autophagy through mTOR signalling pathways in the lung of SD rats. BIOMEDICINE & PHARMACOTHERAPY Biomed Pharmacother. 2021 Mar;135:111034 IF,IHC,WB Rat 1:100,1: 500,1:100 Lung WTRL1 cell
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Zhang, Han, et al. "Kuntai capsule attenuates premature ovarian failure through the PI3K/AKT/mTOR pathway." Journal of ethnopharmacology (2019): 111885.
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Cadmium induces BNIP3-dependent autophagy in chicken spleen by modulating miR-33-AMPK axis. CHEMOSPHERE 2017 Dec 06 WB Chicken 1:1000 Spleen
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6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway PHYTOTHERAPY RESEARCH Hui Zhang WB Human
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The natural medicinal fungus Huaier promotes the anti-hepatoma efficacy of sorafenib through the mammalian target of rapamycin-mediated autophagic cell death MEDICAL ONCOLOGY Zhengguang Zhang WB Mouse, Human
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UQCRFS1 serves as a prognostic biomarker and promotes the progression of ovarian cancer. Jing Wang WB Human 1:1000 ovarian tissue A2780 cell,OVCAR8 cell
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ZEA mediates autophagy through the ROS-AMPK-m-TOR pathway to enhance the susceptibility of mastitis induced by Staphylococcus aureus in mice. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Xiaoyu Hu WB Mouse mouse mammary epithelial cells (MMEC)
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Synthesis of peiminine derivatives and its effect on A549 lung cancer-bearing mice Chemical Biology & Drug Design Xin Jin WB Mouse A549 cell-Xenograft
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The Glycyrrhiza glabra L. crude extract alleviates lipid accumulation in NAFLD by activating Nrf2 and promoting autophagy Journal of Functional Foods Yunfei Wei WB Mouse,Human 1:1000 liver tissue HepG2 cell
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