• 靶点：
• Caspase-9

• 简介：
• >>Platinum drug resistance;>>p53 signaling pathway;>>PI3K-Akt signaling pathway;>>Apoptosis;>>Apoptosis - multiple species;>>VEGF signaling pathway;>>Thyroid hormone signaling pathway;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Pathogenic Escherichia coli infection;>>Legionellosis;>>Toxoplasmosis;>>Tuberculosis;>>Hepatitis C;>>Hepatitis B;>>Measles;>>Human cytomegalovirus infection;>>Influenza A;>>Kaposi sarcoma-associated herpesvirus infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Human immunodeficiency virus 1 infection;>>Pathways in cancer;>>Colorectal cancer;>>Pancreatic cancer;>>Endometrial cancer;>>Prostate cancer;>>Small cell lung cancer;>>Non-small cell lung cancer;>>Viral myocarditis;>>Lipid and atherosclerosis

• 基因名称：
• CASP9

• 蛋白名称：
• Caspase9

• Human Gene Id：
• 842

• Human Swiss Prot No：
• P55211

• Rat Gene Id：
• 58918

• Rat Swiss Prot No：
• Q9JHK1

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CASP9;MCH6;Caspase-9;CASP-9;Apoptotic protease Mch-6;Apoptotic protease-activating factor 3;APAF-3;ICE-like apoptotic protease 6;ICE-LAP6

• 分子量：
• 46kD

• 实测条带：
• 40kD

• 背景：
• This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013],

• 功能：
• catalytic activity:Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-|-Xaa.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).,function:Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.,online information:Caspase-9 entry,PTM:Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 1 CARD domain.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers

• 细胞定位：
• Cytoplasm

• 组织表达：
• Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.

Decreased thioredoxin reductase 3 expression promotes nickel-induced damage to cardiac tissue via activating oxidative stress-induced apoptosis and inflammation
货号：YM8173

Synthesis of macromolecular Astragalus polysaccharide-nano selenium complex and the inhibitory effects on HepG2 cells WB Human /HepG2 cell
货号：YM8173

The inhibitory effects of selenium nanoparticles modified by fructose-enriched polysaccharide from Codonopsis pilosula on HepG2 cells. INDUSTRIAL CROPS AND PRODUCTS Ind Crop Prod. 2022 Feb;176:114335 WB Human HepG2 cell
货号：YM8173

Microcystin-LR Induced Apoptosis in Rat Sertoli Cells via the Mitochondrial Caspase-Dependent Pathway: Role of Reactive Oxygen Species. Frontiers in Physiology 2016 Sep 09 WB Rat Sertoli cell
货号：YM8173

Atrazine Causes Autophagy- and Apoptosis-Related Neurodegenerative Effects in Dopaminergic Neurons in the Rat Nigrostriatal Dopaminergic System. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2015 Jun 12 WB Rat ventral midbrain
货号：YM8173

Effect of annexin A7 suppression on the apoptosis of gastric cancer cells. MOLECULAR AND CELLULAR BIOCHEMISTRY Mol Cell Biochem. 2017 May;429(1):33-43 WB Human,Mouse BGC823 cell-xenograft BGC823 cell
货号：YM8173

Forkhead Box Protein M1 Promotes Nasopharyngeal Carcinoma Cell Tumorigenesis Possibly via the Wnt/β-Catenin Signaling Pathway. MEDICAL SCIENCE MONITOR Med Sci Monitor. 2021; 27: e931970-1–e931970-10 WB Mouse CNE-1s，CNE-2s
货号：YM8173

The role of Se content in improving anti-tumor activities and its potential mechanism for selenized Artemisia sphaerocephala polysaccharides. Food & Function Food Funct. 2021 Mar;12(5):2058-2074 WB Human HepG2 cell
货号：YM8173

SPAG6 silencing inhibits the growth of the malignant myeloid cell lines SKM-1 and K562 via activating p53 and caspase activation-dependent apoptosis. INTERNATIONAL JOURNAL OF ONCOLOGY 2015 Feb 01 WB Human SKM-1 cell， K562 cell
货号：YM8173

Mitochondrial pathway and endoplasmic reticulum stress participate in the photosensitizing effectiveness of AE‐PDT in MG63 cells. Cancer Medicine 2016 Oct 03 WB Human MG63 cell
货号：YM8173

LC3-II may mediate ATR-induced mitophagy in dopaminergic neurons through SQSTM1/p62 pathway. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 2018 Oct 01 WB Rat 1:1000 substantia nigra (SNpc) PC-12 cell
货号：YM8173

Ad-p53 enhances the sensitivity of triple-negative breast cancer MDA-MB-468 cells to the EGFR inhibitor gefitinib. ONCOLOGY REPORTS 2014 Dec 11 WB Human MDA-MB-468 cell
货号：YM8173

VX-680 induces p53-mediated apoptosis in human cholangiocarcinoma cells. ANTI-CANCER DRUGS Anti-Cancer Drug. 2018 Nov;29(10):1004-1010 WB Human 1 : 1000 HCCC-9810 cell
货号：YM8173

5,6-Dihydroxy-3,7,4′-trimethoxyflavonol induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH J Asian Nat Prod Res. 2016;18(11):1079-1090 WB Human 1:1000 HepG-2 cell
货号：YM8173

Apoptosis triggered by pyropheophorbide-α methyl ester-mediated photodynamic therapy in a giant cell tumor in bone. LASER PHYSICS Laser Phys. 2014 May;24(6):066002 WB Human SGC-0404 cell
货号：YM8173

Down-regulation of FoxM1 by thiostrepton or small interfering RNA inhibits proliferation, transformation ability and angiogenesis, and induces apoptosis of nasopharyngeal carcinoma cells. International Journal of Clinical and Experimental Pathology Int J Clin Exp Patho. 2014; 7(9): 5450–5460 WB Human Nasopharyngeal carcinoma (NPC) cell
货号：YM8173

Fucoidan inhibits proliferation of the SKM-1 acute myeloid leukaemia cell line via the activation of apoptotic pathways and production of reactive oxygen species. Molecular Medicine Reports Mol Med Rep. 2015 Nov;12(5):6649-6655 WB Human SKM-1 cell
货号：YM8173

Mitochondrial separation protein inhibitor inhibits cell apoptosis in rat lungs during intermittent hypoxia. Experimental and Therapeutic Medicine 2019 Mar 01 WB Human,Rat 1:1000 lung WRTL1 cell
货号：YM8173

5, 6-Dihydroxy-3, 7, 4′-trimethoxyflavonol induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells." Journal of Asian natural products research 18.11 (2016): 1079-1090.
货号：YM8173

Mitochondrial pathway and endoplasmic reticulum stress participate in the photosensitizing effectiveness of AE‐PDT in MG63 cells. Cancer Medicine 2016 Oct 03 WB Human MG63 cell
货号：YM8173

Flavonoid-Rich Extract of Oldenlandia diffusa (Willd.) Roxb. Inhibits Gastric Cancer by Activation of Caspase-Dependent Mitochondrial Apoptosis Chinese Journal of Integrative Medicine Qiu-lan Wang WB Human
货号：YM8173

Flavonoid-Rich Extract of Oldenlandia diffusa (Willd.) Roxb. Inhibits Gastric Cancer by Activation of Caspase-Dependent Mitochondrial Apoptosis Chinese Journal of Integrative Medicine Qiu-lan Wang WB Human
货号：YM8173

Role of Txnrd3 in NiCl2-induced kidney cell apoptosis in mice: Potential therapeutic effect of melatonin. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Ziwei Zhang WB Mouse 1:2000 kidney
货号：YM8173

The outer membrane protein Tp92 of Treponema pallidum delays human neutrophil apoptosis via the ERK, PI3K/Akt, and NF-κB pathways. MOLECULAR MICROBIOLOGY Yimou Wu WB Human human polymorphonuclear neutrophils (hPMNs)
货号：YM8173

Protective effect of cornuside on OGD/R injury in SH-SY5Y cells and its underlying mechanism. BRAIN RESEARCH Jianwei Gong WB Human SH-SY5Y cell
货号：YM8173

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