• 靶点：
• Cyclin D1

• 简介：
• >>Endocrine resistance;>>FoxO signaling pathway;>>Cell cycle;>>p53 signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Cellular senescence;>>Wnt signaling pathway;>>Hedgehog signaling pathway;>>Apelin signaling pathway;>>Hippo signaling pathway;>>Focal adhesion;>>Tight junction;>>JAK-STAT signaling pathway;>>Prolactin signaling pathway;>>Thyroid hormone signaling pathway;>>Oxytocin signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Cushing syndrome;>>Alcoholic liver disease;>>Hepatitis C;>>Measles;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Human T-cell leukemia virus 1 infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Epstein-Barr virus infection;>>Pathways in cancer;>>Viral carcinogenesis;>>Proteoglycans in cancer;>>MicroRNAs in cancer;>>Chemical carcinogenesis - receptor activation;>>Colorectal cancer;>>Pancreatic cancer;>>Endometrial cancer;>>Glioma;>>Prostate cancer;>>Thyroid cancer;>>Melanoma;>>Bla

• 基因名称：
• CCND1

• 蛋白名称：
• G1/S-specific cyclin-D1

• Human Gene Id：
• 595

• Human Swiss Prot No：
• P24385

• Mouse Gene Id：
• 12443

• Mouse Swiss Prot No：
• P25322

• Rat Gene Id：
• 58919

• Rat Swiss Prot No：
• P39948

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:200-1:1000,WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200,

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CCND1;BCL1;PRAD1;G1/S-specific cyclin-D1;B-cell lymphoma 1 protein;BCL-1;BCL-1 oncogene;PRAD1 oncogene

• 分子量：
• 34kD

• 实测条带：
• 36kD

• 背景：
• The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008],

• 功能：
• disease:A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle.,disease:A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500]. Translocation t(11;14)(q13;q32) with the IgH locus.,disease:A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM:168461]. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer.,function:Essential for the control of the cell cycle at the G1/S (start) transition.,online information:The Singapore human mutation and polymorphism database,PTM:Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31.

• 细胞定位：
• Nucleus

• 组织表达：
• Brain,Placenta,Tongue,

Exosomal transfer of miR-181b-5p confers senescence-mediated doxorubicin resistance via modulating BCLAF1 in breast cancer BRITISH JOURNAL OF CANCER Zhao, Shaorong, Pan, Teng, Deng, Jinhai, Cao, Lixia, Vicencio, Jose M., Liu, Jingjing, Zhou, Guanglin, Ng, Tony, Zhang, Jin WB Human Cal51 cell, MCF-7 cell
货号：YM8149

Licoflavone A Suppresses Gastric Cancer Growth and Metastasis by Blocking the VEGFR-2 Signaling Pathway. Journal of Oncology2022;2022:5497991. Human 1 : 1000 MKN-45 cell
货号：YM8149

TIPE3 promotes non-small cell lung cancer progression via the protein kinase B/extracellular signal-regulated kinase 1/2-glycogen synthase kinase 3β-β-catenin/Snail axis. Translational Lung Cancer Research Transl Lung Cancer R. 2021 Feb; 10(2): 936–954 WB,IF Human,Mouse 1:1000,1:100 Lung cancer tissues, H1299-xenograft，H292-xenograft，A549-xenograft A549s, H1975s, H1299s, H292s
货号：YM8149

Targeting FoxM1 by thiostrepton inhibits growth and induces apoptosis of laryngeal squamous cell carcinoma. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 2014 Nov 13 WB Human Hep-2 cell
货号：YM8149

The transcription factor FOXO4 is down-regulated and inhibits tumor proliferation and metastasis in gastric cancer. BMC CANCER Bmc Cancer. 2014 Dec;14(1):1-11 WB Human 1:1000 gastric cancer(GC) tissue
货号：YM8149

Chidamide Inhibits Acute Myeloid Leukemia Cell Proliferation by lncRNA VPS9D1-AS1 Downregulation via MEK/ERK Signaling Pathway. Frontiers in Pharmacology Front Pharmacol. 2020; 11: 569651 WB Human SKM-1 cell,THP-1 cell
货号：YM8149

Nigericin Exerts Anticancer Effects on Human Colorectal Cancer Cells by Inhibiting Wnt/β-catenin Signaling Pathway. MOLECULAR CANCER THERAPEUTICS Mol Cancer Ther. 2018 May;17(5):952-965 WB Human SW620 cell，KM12 cell
货号：YM8149

Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 signaling. ONCOLOGY REPORTS Oncol Rep. 2020 Sep;44(3):959-972 WB,IHC Human 1 : 1000,1:100 Lung cancer TMA section A549 cell, H292 cell
货号：YM8149

The antitumor effect of hinesol, extract from Atractylodes lancea (Thunb.) DC. by proliferation, inhibition, and apoptosis induction via MEK/ERK and NF‐κB pathway in non–small cell lung cancer cell lines A549 and NCI‐H1299. JOURNAL OF CELLULAR BIOCHEMISTRY 2019 Jul 24 WB Human A549 cell
货号：YM8149

METTL3 attenuates proliferative vitreoretinopathy and epithelial‐mesenchymal transition of retinal pigment epithelial cells via wnt/β‐catenin pathway. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE J Cell Mol Med. 2021 May;25(9):4220-4234 WB Human 1 : 1000 ARPE-19 cell
货号：YM8149

Resveratrol Ameliorates the Anxiety- and Depression-Like Behavior of Subclinical Hypothyroidism Rat: Possible Involvement of the HPT Axis, HPA Axis, and Wnt/β-Catenin Pathway. Frontiers in Endocrinology Front Endocrinol. 2016 May;0:44 WB Rat 1:1000 hippocampus
货号：YM8149

Docosahexaenoic acid inhibits monocrotaline-induced pulmonary hypertension via attenuating endoplasmic reticulum stress and inflammation. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY Am J Physiol-Lung C. 2018 Feb;314(2):L243-L255 WB Rat lung tissue PASMCs
货号：YM8149

Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells. Frontiers in Pharmacology Front Pharmacol. 2019 Mar;0:260 WB Human H1975 cell
货号：YM8149

Final-2 targeted glycolysis mediated apoptosis and autophagy in human lung adenocarcinoma cells but failed to inhibit xenograft in nude mice. FOOD AND CHEMICAL TOXICOLOGY Food Chem Toxicol. 2019 Aug;130:1 WB Human A549 cell,SK-MEL-28 cell
货号：YM8149

Dietary sulforaphane inhibits histone deacetylase activity in B16 melanoma cells. Journal of Functional Foods 2015 Jul 28 WB Human,Mouse B16 melanoma cell,U251 cell
货号：YM8149

Attenuation of the degenerative effects of endothelin-1 on cartilaginous end plate cells by the endothelin receptor antagonist BQ-123 via the Wnt/β-catenin signaling pathway. Spine Journal Spine J. 2018 Sep;18:1669 WB Rabbit cartilaginous end plate cells (CECs)
货号：YM8149

Endothelin-1 Activates the Notch Signaling Pathway and Promotes Tumorigenesis in Giant Cell Tumor of the Spine. SPINE Spine. 2019 Sep;44(17):E1000-E1009 WB Human 1:500 giant cell tumor (GCT) tissue
货号：YM8149

Down-regulation of FoxM1 by thiostrepton or small interfering RNA inhibits proliferation, transformation ability and angiogenesis, and induces apoptosis of nasopharyngeal carcinoma cells. International Journal of Clinical and Experimental Pathology Int J Clin Exp Patho. 2014; 7(9): 5450–5460 WB Human Nasopharyngeal carcinoma (NPC) cell
货号：YM8149

Effect of metformin on apoptosis, cell cycle arrest migration and invasion of A498 cells. Molecular Medicine Reports 2014 Mar 31 WB Human A498 cell
货号：YM8149

5,6-Dihydroxy-3,7,4′-trimethoxyflavonol induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH J Asian Nat Prod Res. 2016;18(11):1079-1090 WB Human 1:1000 HepG-2 cell
货号：YM8149

Panobinostat reverses HepaCAM gene expression and suppresses proliferation by increasing histone acetylation in prostate cancer. GENE Gene. 2022 Jan;808:145977 WB Human LNCaP cell，DU145 cell
货号：YM8149

Insulin-like growth factor II mRNA binding protein 3 regulates proliferation, invasion and migration of neuroendocrine cancer cells. International Journal of Clinical and Experimental Pathology Int J Clin Exp Patho. 2017; 10(10): 10269–10275 WB Mouse STC-1 cell
货号：YM8149

Maekawa, Fumihiko. "Jin-Fang Ge*†, Ya-Yun Xu†, Gan Qin, Jiang-Qun Cheng and Fei-Hu Chen." Chemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches (2017): 138.
货号：YM8149

潘晓菲, et al. "长链非编码 RNA CTB-147C22. 8 对复发性呼吸道乳头状瘤上皮细胞内蛋白表达的影响." 中国耳鼻咽喉头颈外科 27.3 (2021): 171.
货号：YM8149

Final-2 targeted glycolysis mediated apoptosis and autophagy in human lung adenocarcinoma cells but failed to inhibit xenograft in nude mice. FOOD AND CHEMICAL TOXICOLOGY Food Chem Toxicol. 2019 Aug;130:1 WB Human A549 cell,SK-MEL-28 cell
货号：YM8149

Effect of Fumonisin B1 on Proliferation and Apoptosis of Intestinal Porcine Epithelial Cells Toxins Tianjie Wang WB Pig
货号：YM8149

Voacamine is a novel inhibitor of EGFR exerting oncogenic activity against colorectal cancer through the mitochondrial pathway PHARMACOLOGICAL RESEARCH Sanjun Shi WB Human
货号：YM8149

FGF12 regulates cell cycle gene expression and promotes follicular granulosa cell proliferation through ERK phosphorylation in geese. Xingyong Chen WB Geese 1:1000 granulosa cell
货号：YM8149

Bruceine A: Suppressing metastasis via MEK/ERK pathway and invoking mitochondrial apoptosis in triple-negative breast cancer. BIOMEDICINE & PHARMACOTHERAPY Jun Lu WB Mouse,Human 1:1000 MDA-MB-231 cell,4T1 cell
货号：YM8149

L-Theanine delays D-galactose-induced senescence by regulating the cell cycle and inhibiting apoptosis in rat intestinal cells JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE Wei Xu WB Rat 1:2000 IEC-6 cell
货号：YM8149

Tafazzin mediates tamoxifen resistance by regulating cellular phospholipid composition in ER-positive breast cancer CANCER GENE THERAPY Li Xuan WB Human 1:1000 MCF7 cell,ZR-75-1 cell
货号：YM8149

4-Hydroxy-2-pyridone derivatives with antitumor activity produced by mangrove endophytic fungus Talaromyces sp. CY-3 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Wencong Yang WB Human 1:1000 A549 cell,H1703 cell
货号：YM8149

L-theanine protects against D-galactose-induced aging in L6 skeletal muscle cells Journal of Functional Foods Min Long WB Rat 1:2000 L6 cell
货号：YM8149

Deficiency of smooth muscle cell ILF3 alleviates intimal hyperplasia via HMGB1 mRNA degradation-mediated regulation of the STAT3/DUSP16 axis JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY Ya-min Hou IHC Mouse neointima tissue
货号：YM8149

Exosomes Derived from Adipose Mesenchymal Stem Cells Promote Regeneration of Injured Liver in Minipigs INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Yue Wang WB Pig 1:1000 liver tissue
货号：YM8149

Dexmedetomidine facilitates autophagic flux to promote liver regeneration by suppressing GSK3β activity in mouse partial hepatectomy BIOMEDICINE & PHARMACOTHERAPY Xueya Yao WB Mouse 1:1000 liver tissue primary mouse hepatocytes,AML-12 cell
货号：YM8149

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