• 靶点：
• FoxO1

• 简介：
• >>FoxO signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Cellular senescence;>>Insulin signaling pathway;>>Thyroid hormone signaling pathway;>>Glucagon signaling pathway;>>Insulin resistance;>>AGE-RAGE signaling pathway in diabetic complications;>>Alcoholic liver disease;>>Shigellosis;>>Human papillomavirus infection;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Prostate cancer

• 基因名称：
• FOXO1

• 蛋白名称：
• Forkhead box protein O1

• Human Gene Id：
• 2308

• Human Swiss Prot No：
• Q12778

• Mouse Gene Id：
• 56458

• Mouse Swiss Prot No：
• Q9R1E0

• Rat Gene Id：
• 84482

• Rat Swiss Prot No：
• G3V7R4

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:400-1000,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• FOXO1;FKHR;FOXO1A;Forkhead box protein O1;Forkhead box protein O1A;Forkhead in rhabdomyosarcoma

• 分子量：
• 75kD

• 实测条带：
• 75kD

• 背景：
• This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3; translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.,function:Transcription factor.,PTM:Phosphorylated by AKT1; insulin-induced (By similarity). IGF1 rapidly induces phosphorylation of Ser-256, Thr-24, and Ser-319. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24, and Ser-319, permitting phosphorylation of Ser-322 and Ser-325, probably by CK1, leading to nuclear exclusion and loss of function. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 fork-head DNA-binding domain.,subcellular location:Shuttles betw

• 细胞定位：
• Nucleus

• 组织表达：
• Ubiquitous.

Quantitative proteomic characterization and comparison of T helper 17 and induced regulatory T cells. PLOS BIOLOGY 2018 May 31 WB Mouse T helper 17 (Th17) cell
货号：YM8135

Overexpression of HepaCAM inhibits bladder cancer cell proliferation and viability through the AKT/FoxO pathway. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY J Cancer Res Clin. 2017 May;143(5):793-805 WB Human 1:1000 Bca cell
货号：YM8135

Screening active components from Rubus amabilis for pancreatic β-cells protection. PHARMACEUTICAL BIOLOGY Pharm Biol. 2020;58(1):674-685 WB Mouse MIN6 cells
货号：YM8135

Paclitaxel alleviates monocrotaline-induced pulmonary arterial hypertension via inhibition of FoxO1-mediated autophagy. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 2019 Jan 25 WB Rat 1:1000 lung tissues
货号：YM8135

Effects of metformin on clinical, hormonal and relevant gene expression parameters in patients of acne – an observational study CLINICAL AND EXPERIMENTAL DERMATOLOGY Dipankar De IHC Human sebaceous glands, eccrine glands keratinocytes
货号：YM8135

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