• 靶点：
• LDHA;LDHB;LDHC

• 简介：
• >>Glycolysis / Gluconeogenesis;>>Cysteine and methionine metabolism;>>Pyruvate metabolism;>>Propanoate metabolism;>>Metabolic pathways;>>HIF-1 signaling pathway;>>Glucagon signaling pathway;>>Central carbon metabolism in cancer

• 基因名称：
• LDHA;PIG19;LDHB;LDHC;LDH3;LDHX;

• 蛋白名称：
• L-lactate dehydrogenase A chain;LDH-A;Cell proliferation-inducing gene 19 protein;LDH muscle subunit;LDH-M;Renal carcinoma antigen NY-REN-59;L-lactate dehydrogenase B chain;LDH-B;LDH heart subunit;LDH

• Human Gene Id：
• 3939

• Human Swiss Prot No：
• P00338;P07195;P07864;

• Mouse Swiss Prot No：
• P06151

• Rat Swiss Prot No：
• P04642

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:1000-3000,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• LDHA;PIG19;LDHB;LDHC;LDH3;LDHX;L-lactate dehydrogenase A chain;LDH-A;Cell proliferation-inducing gene 19 protein;LDH muscle subunit;LDH-M;Renal carcinoma antigen NY-REN-59;L-lactate dehydrogenase B chain;LDH-B;LDH heart subunit;LDH-H;Renal carcinoma antigen NY-REN-46;L-lactate dehydrogenase C chain;LDH-C;Cancer/testis antigen 32;CT32;LDH testis subunit;LDH-X;

• 分子量：
• 37kD

• 实测条带：
• 37kD

• 背景：
• The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008],

• 功能：
• catalytic activity:(S)-lactate + NAD(+) = pyruvate + NADH.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in LDHA are a cause of exertional myoglobinuria.,online information:Lactate dehydrogenase entry,pathway:Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.,similarity:Belongs to the LDH/MDH superfamily.,similarity:Belongs to the LDH/MDH superfamily. LDH family.,subunit:Homotetramer.,

• 细胞定位：
• Cytoplasmic, Membranous

• 组织表达：
• Predominantly expressed in anaerobic tissues such as skeletal muscle and liver.

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