• 靶点：
• Cyclin E1

• 简介：
• >>Cell cycle;>>Oocyte meiosis;>>p53 signaling pathway;>>PI3K-Akt signaling pathway;>>Cellular senescence;>>Cushing syndrome;>>Hepatitis B;>>Measles;>>Human papillomavirus infection;>>Human T-cell leukemia virus 1 infection;>>Epstein-Barr virus infection;>>Pathways in cancer;>>Viral carcinogenesis;>>MicroRNAs in cancer;>>Prostate cancer;>>Small cell lung cancer;>>Gastric cancer

• 基因名称：
• CCNE1

• 蛋白名称：
• G1/S-specific cyclin-E1

• Human Gene Id：
• 898

• Human Swiss Prot No：
• P24864

• Mouse Gene Id：
• 12447

• Mouse Swiss Prot No：
• Q61457

• Rat Swiss Prot No：
• P39949

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:400-1000,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CCNE1;CCNE;G1/S-specific cyclin-E1

• 分子量：
• 47kD

• 实测条带：
• 47kD

• 背景：
• The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in

• 功能：
• function:Essential for the control of the cell cycle at the G1/S (start) transition.,PTM:Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the cyclin family. Cyclin E subfamily.,subunit:Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1.,tissue specificity:Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.,

• 细胞定位：
• Nuclear

• 组织表达：
• Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.

Melatonin treatment improves human umbilical cord mesenchymal stem cell therapy in a mouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway. Stem Cell Research & Therapy2022 Dec;13(1):1-15. Human,Mouse 1:1200 liver tissue hUC-MSC
货号：YM8098

TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways. Cell Death & Disease Cell Death Dis. 2020 Jan;11(1):1-15 WB Rat heart
货号：YM8098

Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα and cell-cycle-driving proteins. Scientific Reports Sci Rep-Uk. 2016 Jan;6(1):1-10 IHC Mouse 1:100 mammary gland
货号：YM8098

Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 signaling. ONCOLOGY REPORTS Oncol Rep. 2020 Sep;44(3):959-972 WB,IHC Human 1 : 1000,1:00 Lung cancer TMA section A549 cell, H292 cell
货号：YM8098

Targeting FoxM1 by thiostrepton inhibits growth and induces apoptosis of laryngeal squamous cell carcinoma. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 2014 Nov 13 WB Human Hep-2 cell
货号：YM8098

TNAP is a novel regulator of cardiac fibrosis after myocardial infarction by mediating TGF-β/Smads and ERK1/2 signaling pathways. EBioMedicine Ebiomedicine. 2021 May;67:103370 WB Mouse 1 : 1000 Heart tissues CFs
货号：YM8098

Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 2016 Dec 01 WB Human U2OS cell
货号：YM8098

Down-regulation of FoxM1 by thiostrepton or small interfering RNA inhibits proliferation, transformation ability and angiogenesis, and induces apoptosis of nasopharyngeal carcinoma cells. International Journal of Clinical and Experimental Pathology Int J Clin Exp Patho. 2014; 7(9): 5450–5460 WB Human Nasopharyngeal carcinoma (NPC) cell
货号：YM8098

The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation. PROTEIN JOURNAL Protein J. 2018 Apr;37(2):132-143 WB Human HEK293T cell, HeLa cell
货号：YM8098

Zhang, Peng, et al. "Tubulin cofactor A functions as a novel positive regulator of ccRCC progression, invasion and metastasis." International journal of cancer 133.12 (2013): 2801-2811.
货号：YM8098

潘晓菲, et al. "长链非编码 RNA CTB-147C22. 8 对复发性呼吸道乳头状瘤上皮细胞内蛋白表达的影响." 中国耳鼻咽喉头颈外科 27.3 (2021): 171.
货号：YM8098

Effect of Fumonisin B1 on Proliferation and Apoptosis of Intestinal Porcine Epithelial Cells Toxins Tianjie Wang WB Pig
货号：YM8098

Protective effect of cornuside on OGD/R injury in SH-SY5Y cells and its underlying mechanism. BRAIN RESEARCH Jianwei Gong WB Human SH-SY5Y cell
货号：YM8098

Salvianolic acid A alleviates H2O2-induced endothelial oxidative injury via miR-204-5p Scientific Reports Qiao Xilin WB Human 1:1000 human umbilical vein endothelial cell (HUVEC)
货号：YM8098

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