• 靶点：
• N-cadherin

• 简介：
• >>Cell adhesion molecules;>>Arrhythmogenic right ventricular cardiomyopathy

• 基因名称：
• CDH2 CDHN NCAD

• 蛋白名称：
• Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)

• Human Gene Id：
• 1000

• Human Swiss Prot No：
• P19022

• Mouse Gene Id：
• 12558

• Mouse Swiss Prot No：
• P15116

• Rat Gene Id：
• 83501

• Rat Swiss Prot No：
• Q9Z1Y3

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:500-1:2000,WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200,

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CDH2;CDHN;NCAD;Cadherin-2;CDw325;Neural cadherin;N-cadherin;CD antigen CD325

• 分子量：
• 125kD

• 实测条带：
• 130kD

• 背景：
• This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015],

• 功能：
• function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism.,similarity:Contains 5 cadherin domains.,subunit:Interacts with CDCP1.,

• 细胞定位：
• Membrane

• 组织表达：
• Brain,Epithelium,Liver,

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Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9. ACTA PHARMACOLOGICA SINICA2022 Apr;:1-10. Human 1:1000 A549 cell, NCI-H1299 cell
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Licoflavone A Suppresses Gastric Cancer Growth and Metastasis by Blocking the VEGFR-2 Signaling Pathway. Journal of Oncology2022;2022:5497991. Human 1 : 1000 MKN-45 cell
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A connexin43/YAP axis regulates astroglial-mesenchymal transition in hemoglobin induced astrocyte activation. CELL DEATH AND DIFFERENTIATION 2018 Jun 07 WB Rat 1:1000 Astrocytes
货号：YM8097

SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2. CELL DEATH AND DIFFERENTIATION 2018 Jul 09 IHC Human breast cancer tissue
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Tanshinone IIA mediates SMAD7-YAP interaction to inhibit liver cancer growth by inactivating the transforming growth factor beta signaling pathway. Aging-US Aging-Us. 2019 Nov 15; 11(21): 9719–9737 WB Human 1:2000 Bel-7404 cell, SMMC-7721 cell
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N6-Methyladenosine Modification of CDH1 mRNA Promotes PM2.5-Induced Pulmonary Fibrosis via Mediating Epithelial Mesenchymal Transition. TOXICOLOGICAL SCIENCES Toxicol Sci. 2021 Nov;: WB Mouse,Human 1:1000 Lung BEAS-2B cell
货号：YM8097

Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6. Journal of Immunology Research J Immunol Res. 2021;2021:8875450 WB Human 1 : 1000 SKOV3 cell
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Integration of exosomal miR-106a and mesothelial cells facilitates gastric cancer peritoneal dissemination. CELLULAR SIGNALLING Cell Signal. 2022 Mar;91:110230 WB Human 1:1000 HMrSV5 cell
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Mesenchymal stem cell‑derived extracellular vesicles promote the in vitro proliferation and migration of breast cancer cells through the activation of the ERK pathway. INTERNATIONAL JOURNAL OF ONCOLOGY Int J Oncol. 2019 May;54(5):1843-1852 WB Human 1:1000 hUC-MSC-EVs
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Huaier Restrains Proliferative and Migratory Potential of Hepatocellular Carcinoma Cells Partially Through Decreased Yes-Associated Protein 1. Journal of Cancer J Cancer. 2017; 8(19): 4087–4097 WB Human Bel-7404 cell,SMMC-7721 cell
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LncRNA GAS6-AS1 facilitates tumorigenesis and metastasis of colorectal cancer by regulating TRIM14 through miR-370-3p/miR-1296-5p and FUS Journal of Translational Medicine Jie Wu WB Human
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货号：YM8097

circRNAs deregulation in exosomes derived from BEAS-2B cells is associated with vascular stiffness induced by PM2.5 Journal of Environmental Sciences Rong Zhang WB Human human bronchial epithelial cell line (BEAS-2B)
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Nanocarrier of Pin1 inhibitor based on supercritical fluid technology inhibits cancer metastasis by blocking multiple signaling pathways Regenerative Biomaterials Dayun Yang WB,IHC Human,Mouse lung tissues HuH7 cell,HepG2 cell
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NMT1 sustains ICAM-1 to modulate adhesion and migration of tumor cells. Yongxia Qiao WB Human 1:500 Bel-7402 cell,Bel-7404 cell
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Bufalin inhibits the proliferation of lung cancer cells by suppressing Hippo-YAP pathway. Yongchun Yu WB Human A549 cell
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The combination of inositol hexaphosphate and inositol inhibits metastasis of colorectal cancer cells by upregulating claudin 7. Yang Song WB Human SW480 cell,SW620 cell
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Tangeretin attenuates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition via the PI3K/Akt pathway. Frontiers in Pharmacology Pengfei Yi WB Human，Mouse lung tissue A549 cell
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Carbon black induced pulmonary fibrosis through piR-713551/PIWIL4 targeting THBS2 signal pathway Journal of Environmental Sciences Mengruo Wang WB Human,Mouse lung tissue BEAS-2B cell
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Mutant p53 achieves function by regulating EGR1 to induce epithelial mesenchymal transition TISSUE & CELL Weipei Meng WB Human H1299 cell
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