• 靶点：
• STING/TMEM173

• 简介：
• >>NOD-like receptor signaling pathway;>>RIG-I-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway;>>Shigellosis;>>Human cytomegalovirus infection;>>Herpes simplex virus 1 infection;>>Human immunodeficiency virus 1 infection;>>Coronavirus disease - COVID-19

• 基因名称：
• TMEM173 ERIS MITA STING

• 蛋白名称：
• Transmembrane protein 173

• Human Gene Id：
• 340061

• Human Swiss Prot No：
• Q86WV6

• Mouse Gene Id：
• 72512

• Mouse Swiss Prot No：
• Q3TBT3

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:200-1000,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TMEM173;ERIS;MITA;STING;Transmembrane protein 173;Endoplasmic reticulum interferon stimulator;ERIS;Mediator of IRF3 activation;hMITA;Stimulator of interferon genes protein;hSTING

• 分子量：
• 42kD

• 实测条带：
• 37kD

• 背景：
• This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014],

• 功能：
• function:Acts as a facilitator of innate immune signaling. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.,PTM:Phosphorylated on tyrosine residues upon MHC-II aggregation.,subunit:Associates with the MHC-II complex (By similarity). Interacts with DDX58/RIG-I, MAVS/VISA and SSR2.,tissue specificity:Ubiquitously expressed.,

• 细胞定位：
• Cytoplasmic, Membranous

• 组织表达：
• Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages.

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