• 靶点：
• CD19

• 基因名称：
• CD19

• 蛋白名称：
• B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)

• Human Gene Id：
• 930

• Human Swiss Prot No：
• P15391

• Mouse Gene Id：
• 12478

• Mouse Swiss Prot No：
• P25918

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:200-1000,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 110kD

• 实测条带：
• 110kD

• 背景：
• CD19 molecule(CD19) Homo sapiens Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008],

• 功能：
• Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens . Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores . Is not required for early steps during B cell differentiation in the blood marrow . Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges . Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge .

• 细胞定位：
• Membranous

• 组织表达：
• Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:2463100). Detected on blood B cells (at protein level) (PubMed:2463100, PubMed:16672701).

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