• 靶点：
• SQSTM1/p62

• 简介：
• >>Mitophagy - animal;>>Autophagy - animal;>>Necroptosis;>>Cellular senescence;>>Osteoclast differentiation;>>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases;>>Shigellosis;>>Fluid shear stress and atherosclerosis

• 基因名称：
• SQSTM1 ORCA OSIL

• 蛋白名称：
• SQSTM

• Human Gene Id：
• 8878

• Human Swiss Prot No：
• Q13501

• Mouse Gene Id：
• 18412

• Mouse Swiss Prot No：
• Q64337

• Rat Gene Id：
• 113894

• Rat Swiss Prot No：
• O08623

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:200-1000,WB 1:500-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 48kD

• 实测条带：
• 60kD

• 背景：
• This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009],

• 功能：
• disease:Defects in SQSTM1 are a cause of sporadic and familial Paget disease of bone (PDB) [MIM:602080]. PDB is a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts. Manifestations of the disease include bone pain, deformity, pathological fractures, deafness, neurological complications and increased risk of osteosarcoma. PDB is a chronic disease affecting 2 to 3% of the population above the age of 40 years.,domain:The OPR domain mediates homooligomerization and interactions with PRKCZ, PRKCI, MAP2K5 and NBR1.,domain:The UBA domain binds specifically 'Lys-63'-linked polyubiquitin chains of polyubiquitinated substrates. Mediates the interaction with TRIM55.,domain:The ZZ-type zinc finger mediates the interaction with RIPK1.,function:Adapter protein which binds ubiquitin and may regul

• 细胞定位：
• Cytoplasm, Nuclear

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