• 靶点：
• CD74

• 简介：
• >>Antigen processing and presentation;>>Tuberculosis;>>Herpes simplex virus 1 infection

• 基因名称：
• CD74 DHLAG

• 蛋白名称：
• CD74

• Human Gene Id：
• 972

• Human Swiss Prot No：
• P04233

• 免疫原：
• Synthesized peptide derived from human CD74 AA range: 150-250

• 特异性：
• This antibody detects endogenous levels of human CD74. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Mouse, Monoclonal/IgG1, Kappa

• 稀释：
• IHC 1:200-400, WB 1:200-1000, ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain;Ia antigen-associated invariant chain;Ii;p33;CD antigen CD74)

• 分子量：
• 34kD

• 背景：
• The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],

• 功能：
• function:Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.,similarity:Contains 1 thyroglobulin type-1 domain.,subunit:Nonamer composed of three alpha/beta/gamma heterotrimers.,

• 细胞定位：
• Cytoplasmic, Membranous

• 组织表达：
• [Isoform p41]: In B cells, represents 10% of total CD74 expression. ; [Isoform p33]: In B cells, represents 70% of total CD74 expression.

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