GATA-3 Monoclonal Antibody (7M11)
- 货号：YM0298
- 应用：WB;IHC;IF;ELISA
- 种属：Human
- 简介：
- >>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>Parathyroid hormone synthesis, secretion and action;>>Inflammatory bowel disease
- 蛋白名称：
- Trans-acting T-cell-specific transcription factor GATA-3
- 免疫原：
- Purified recombinant fragment of human GATA-3 expressed in E. Coli.
- 特异性：
- GATA-3 Monoclonal Antibody detects endogenous levels of GATA-3 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- GATA3;Trans-acting T-cell-specific transcription factor GATA-3;GATA-binding factor 3
- 背景：
- This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009],
- 功能：
- disease:Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.,function:Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.,similarity:Contains 2 GATA-type zinc fingers.,tissue specificity:T-cells and endothelial cells.,
- 组织表达：
- T-cells and endothelial cells.
- Western Blot analysis using GATA-3 Monoclonal Antibody against GATA3-hIgGFc transfected HEK293 cell lysate.
- Immunohistochemistry analysis of paraffin-embedded human Small Intestine, muscularis propria tissues with AEC staining using GATA-3 Monoclonal Antibody.
