GATA-1 Monoclonal Antibody
- 货号：YM0296
- 应用：WB;IHC;IF;ELISA
- 种属：Human
- 蛋白名称：
- Erythroid transcription factor
- 免疫原：
- Purified recombinant fragment of human GATA-1 expressed in E. Coli.
- 特异性：
- GATA-1 Monoclonal Antibody detects endogenous levels of GATA-1 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- GATA1;ERYF1;GF1;Erythroid transcription factor;Eryf1;GATA-binding factor 1;GATA-1;GF-1;NF-E1 DNA-binding protein
- 背景：
- This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008],
- 功能：
- disease:Defects in GATA1 are the cause of X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [MIM:300367]. XDAT is a disorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes.,disease:Defects in GATA1 are the cause of X-linked thrombocytopenia with beta-thalassemia (XLTT) [MIM:314050]; also called thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis. The disease consists of an unusual form of thrombocytopenia with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced (hemo)globin chain synthesis resembling that of beta-thalassemia minor.,domain:The two fingers are functionally distinct and cooperate to achie
- Western Blot analysis using GATA-1 Monoclonal Antibody against K562 (1) cell lysate.
- Immunohistochemistry analysis of paraffin-embedded pancreatic cancer, with DAB staining using GATA-1 Monoclonal Antibody.
- Immunofluorescence analysis of K562(left) cells using GATA-1 Monoclonal Antibody (green). Blue: DRAQ5 fluorescent DNA dye.
