FoxA2 Monoclonal Antibody
- 货号：YM0281
- 应用：WB;IHC;IF;ELISA
- 种属：Human
- 简介：
- >>Longevity regulating pathway - multiple species;>>Maturity onset diabetes of the young
- 蛋白名称：
- Hepatocyte nuclear factor 3-beta
- 免疫原：
- Purified recombinant fragment of FoxA2 expressed in E. Coli.
- 特异性：
- FoxA2 Monoclonal Antibody detects endogenous levels of FoxA2 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- FOXA2;HNF3B;TCF3B;Hepatocyte nuclear factor 3-beta;HNF-3-beta;HNF-3B;Forkhead box protein A2;Transcription factor 3B;TCF-3B
- 背景：
- This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008],
- 功能：
- function:Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes.,online information:Hepatocyte nuclear factors entry,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Binds TLE1.,
- 细胞定位：
- Nucleus . Cytoplasm . Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
- Western Blot analysis using FoxA2 Monoclonal Antibody against A549 (1) cell lysate.
- Immunohistochemistry analysis of paraffin-embedded human colon cancer (A), gastric cancer (B) and rectal cancer (C) tissues with DAB staining using FoxA2 Monoclonal Antibody.
