PF06840003

    • 货号:MC1323
      • CasNo:
      • 198474-05-4
      • 分子式:
      • C12H9FN2O2
      • 纯度:
      • >98%
      • 靶点:
      • Indoleamine 2,3-Dioxygenase (IDO)
      • IC50:
      • No data
      • 体外研究:
      • PF-06840003 reverses IDO-1-induced T-cell anergy in vitro[1].
      • 体内研究:
      • PF-06840003 reduces intratumoral kynurenine levels in mice by >80% and inhibits tumor growth in multiple preclinical syngeneic models in mice, in combination with immune checkpoint inhibitors. PF-0684003 has favorable predicted human pharmacokinetic properties, including a predicted t1/2 of 16-19 hours[1].
      • 简介:
      • PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineoplastic activities.
      • 特异性:
      • Target: Indoleamine 2,3-Dioxygenase (IDO). Fields: PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineopl
      • 浓度:
      • >98%
      • 储存:
      • 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
      • 其他名称:
      • PF 06840003,PF-06840003
      • 分子量:
      • 232.21
      • 产品图片