V-ATPase C2 Polyclonal Antibody

    • Catalog No.：YT4859
    • Applications：WB;ELISA
    • Reactivity：Human;Rat;Mouse;
      • Target：
      • V-ATPase C2
      • Fields：
      • >>Oxidative phosphorylation;>>Metabolic pathways;>>Phagosome;>>mTOR signaling pathway;>>Synaptic vesicle cycle;>>Collecting duct acid secretion;>>Vibrio cholerae infection;>>Epithelial cell signaling in Helicobacter pylori infection;>>Human papillomavirus infection;>>Rheumatoid arthritis
      • Gene Name：
      • ATP6V1C2
      • Protein Name：
      • V-type proton ATPase subunit C 2
      • Human Swiss Prot No：
      • Q8NEY4
      • Mouse Swiss Prot No：
      • Q99L60
      • Immunogen：
      • The antiserum was produced against synthesized peptide derived from human ATP6V1C2. AA range:121-170
      • Specificity：
      • V-ATPase C2 Polyclonal Antibody detects endogenous levels of V-ATPase C2 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Polyclonal, Rabbit,IgG
      • Dilution：
      • WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
      • Purification：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • ATP6V1C2;V-type proton ATPase subunit C 2;V-ATPase subunit C 2;Vacuolar proton pump subunit C 2
      • Observed Band(KD)：
      • 48kD
      • Background：
      • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008],
      • Function：
      • function:Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.,similarity:Belongs to the V-ATPase C subunit family.,subunit:V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).,tissue specificity:Kidney and placenta.,
      • Subcellular Location：
      • vacuolar proton-transporting V-type ATPase, V1 domain,lysosomal membrane,cytosol,proton-transporting V-type ATPase, V1 domain,extracellular exosome,
      • Expression：
      • Kidney and placenta.
      • Products Images
      • Western blot analysis of ATP6V1C2 Antibody. The lane on the right is blocked with the ATP6V1C2 peptide.
      • Western blot analysis of the lysates from HT-29 cells using ATP6V1C2 antibody.

      Attributes

      • Code：
      • YT4859
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 150 / 280 / 450
      • Delivery：
      • 2024-11-23
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