• Target：
• RORγ

• Fields：
• >>Th17 cell differentiation;>>Circadian rhythm;>>Inflammatory bowel disease

• Gene Name：
• RORC

• Protein Name：
• Nuclear receptor ROR-gamma

• Human Gene Id：
• 6097

• Human Swiss Prot No：
• P51449

• Mouse Gene Id：
• 19885

• Mouse Swiss Prot No：
• P51450

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human RORG. AA range:71-120

• Specificity：
• RORγ Polyclonal Antibody detects endogenous levels of RORγ protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• RORC;NR1F3;RORG;RZRG;Nuclear receptor ROR-gamma;Nuclear receptor RZR-gamma;Nuclear receptor subfamily 1 group F member 3;Retinoid-related orphan receptor-gamma

• Observed Band(KD)：
• 58kD

• Background：
• The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• Function：
• function:Orphan nuclear receptor.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,tissue specificity:Highly expressed in skeletal muscle.,

• Subcellular Location：
• Nucleus .

• Expression：
• Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes.

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