• Target：
• REP-2

• Gene Name：
• CHML

• Protein Name：
• Rab proteins geranylgeranyltransferase component A 2

• Human Gene Id：
• 1122

• Human Swiss Prot No：
• P26374

• Mouse Swiss Prot No：
• Q9QZD5

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CHML. AA range:128-177

• Specificity：
• REP-2 Polyclonal Antibody detects endogenous levels of REP-2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CHML;REP2;Rab proteins geranylgeranyltransferase component A 2;Choroideraemia-like protein;Rab escort protein 2;REP-2

• Observed Band(KD)：
• 85kD

• Background：
• The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008],

• Function：
• function:Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family.,miscellaneous:Substitutes for REP-1 thereby preventing widespread tissue abnormalities in patients with choroideremia who lack REP-1.,similarity:Belongs to the Rab GDI family.,subunit:Monomer. Interacts with Rab and Rab GGTase.,

• Subcellular Location：
• Cytoplasm, cytosol .

• Expression：
• Brain,

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