• Target：
• IGSF4B

• Fields：
• >>Cell adhesion molecules

• Gene Name：
• CADM3

• Protein Name：
• Cell adhesion molecule 3

• Human Gene Id：
• 57863

• Human Swiss Prot No：
• Q8N126

• Mouse Gene Id：
• 94332

• Mouse Swiss Prot No：
• Q99N28

• Rat Gene Id：
• 360882

• Rat Swiss Prot No：
• Q1WIM3

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CADM3. AA range:141-190

• Specificity：
• IGSF4B Polyclonal Antibody detects endogenous levels of IGSF4B protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CADM3;IGSF4B;NECL1;SYNCAM3;TSLL1;Cell adhesion molecule 3;Brain immunoglobulin receptor;Immunoglobulin superfamily member 4B;IgSF4B;Nectin-like protein 1;NECL-1;Synaptic cell adhesion molecule 3;SynCAM3;TSLC1-like protein 1;TS

• Observed Band(KD)：
• 43kD

• Background：
• cell adhesion molecule 3(CADM3) Homo sapiens IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed 15741237]).[supplied by OMIM, Mar 2008],

• Function：
• domain:The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.,function:Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.,induction:Markedly in glioma cell lines and prostate cancer cell lines.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Localized at the cell-cell attached sites of the plasma membrane.,subunit:Homodimer. Can form trans-heterodimers with PVRL3/nectin-3. Interacts with EPB41L1, DLG3, MPP6 and CASK.,tissue specificity:Isoform 1 is expressed mainly in adult and fetal brain.

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein . Cell junction .

• Expression：
• Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.

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