• Target：
• PSA

• Fields：
• >>Pathways in cancer;>>Prostate cancer

• Gene Name：
• KLK3

• Protein Name：
• Prostate-specific antigen

• Human Gene Id：
• 354

• Human Swiss Prot No：
• P07288

• Immunogen：
• Purified recombinant fragment of PSA (aa26-251) expressed in E. Coli.

• Specificity：
• PSA Monoclonal Antibody detects endogenous levels of PSA protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• KLK3;APS;Prostate-specific antigen;PSA;Gamma-seminoprotein;Seminin;Kallikrein-3;P-30 antigen;Semenogelase

• Molecular Weight(Da)：
• 29kD

• References：
• 1. Am J Surg Pathol. 2007 Sep;31(9):1351-5.
  2. Chem Biol Drug Des. 2007 Sep;70(3):261-7.

• Background：
• Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:Preferential cleavage: -Tyr-|-Xaa-.,function:Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.,online information:Prostate-specific antigen entry,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,

• Subcellular Location：
• Secreted.

• Expression：
• Leukocyte,PNS,Prostate,

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