Protein Z Monoclonal Antibody

    • Catalog No.：YM0538
    • Applications：WB;ELISA
    • Reactivity：Human
      • Target：
      • Protein Z
      • Gene Name：
      • PROZ
      • Protein Name：
      • Vitamin K-dependent protein Z
      • Human Gene Id：
      • 8858
      • Human Swiss Prot No：
      • P22891
      • Mouse Swiss Prot No：
      • Q9CQW3
      • Immunogen：
      • Purified recombinant fragment of Protein Z expressed in E. Coli.
      • Specificity：
      • Protein Z Monoclonal Antibody detects endogenous levels of Protein Z protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification：
      • Affinity purification
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • PROZ;Vitamin K-dependent protein Z
      • Molecular Weight(Da)：
      • 45kD
      • References：
      • 1. J Thromb Haemost. 2005 Mar;3(3):497-501.
        2. Blood Coagul Fibrinolysis. 2008 Jan;19(1):23-5.
      • Background：
      • This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012],
      • Function：
      • caution:Although homologous with the vitamin K-dependent clotting factors, it has lost two of the essential catalytic residues and has no enzymatic activity.,function:Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 EGF-like domains.,tissue specificity:Plasma.,
      • Subcellular Location：
      • Secreted.
      • Expression：
      • Plasma.
      • Products Images
      • Western Blot analysis using Protein Z Monoclonal Antibody against human plasma (1).

      Attributes

      • Code：
      • YM0538
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-11-30
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