• Target：
• PLAP

• Fields：
• >>Thiamine metabolism;>>Folate biosynthesis;>>Metabolic pathways;>>Biosynthesis of cofactors

• Gene Name：
• ALPP

• Protein Name：
• Alkaline phosphatase, placental type

• Human Gene Id：
• 250

• Human Swiss Prot No：
• P05187

• Immunogen：
• Purified recombinant fragment of human PLAP expressed in E. Coli.

• Specificity：
• PLAP Monoclonal Antibody detects endogenous levels of PLAP protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ALPP;PLAP;Alkaline phosphatase; placental type;Alkaline phosphatase Regan isozyme;Placental alkaline phosphatase 1;PLAP-1

• Molecular Weight(Da)：
• 58kD

• References：
• 1. J Cell Biochem. 2003 Apr 1;88(5):1025-37.
  2. J Mol Biol. 2005 Jul 15;350(3):441-51.

• Background：
• The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015],

• Function：
• catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 2 zinc ions.,miscellaneous:In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).,online information:Alkaline phosphatase entry,polymorphism:Placental ALP is highly polymorphic, there are at least three common alleles.,similarity:Belongs to the alkaline phosphatase family.,subunit:Homodimer.,

• Subcellular Location：
• Cell membrane; Lipid-anchor, GPI-anchor .

• Expression：
• Detected in placenta (at protein level).

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